Pre-heat oven to 350°F.
Line a muffin tray with liners or cooking spray.
In a large bowl, combine the flour, sugar, baking powder, baking soda, salt, and pumpkin spice.
In a separate bowl, combine the pumpkin, melted butter, vanilla extract, and egg.
Combine the wet mixture with the dry mixture and stir until just combined.
Fill muffin liners with batter about 3/4 full.